Author name: Farhan

mycobacterium avium

FDA approved Arikayce for Mycobacterium Avium complex

FDA approved Arikayce (amikacin liposomal inhalation suspension) recently for patients with Mycobacterium-avium complex infections, not responding to conventional treatment. Boxed Warning Boxed warning with Arikayce includes hypersensitivity pneumonitis, bronchospasm, hemoptysis and exacerbation of the underlying chronic lung disease. Other side effects include dysphonia, cough, ototoxicity, upper airway irritation, fatigue, nausea, diarrhea and myalgias. Safety and …

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list of diseases misdiagnosed

Life-threatening diseases often misdiagnosed!!

Here is a list of diseases commonly misdiagnosed. These include a heart attack, stroke and all other conditions which may be life-threatening if not timely diagnosed. Patients with the same medical conditions can present differently. The classic presentation of disease, written in books is present in only a minority of patients in most conditions. Furthermore, …

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brain dead but alive

Brain dead but alive – Physicians must take extra caution!!.

“Brain dead but alive!” There are very few conditions when a person has no brainstem activity and is declared brain dead by the doctors. Physicians must take great caution in declaring patients with these diagnoses as they are actually alive. A true story of a patient in our ward … While conducting rounds in the medical …

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NAFLD

NAFLD (Fatty liver) – Associated with liver cancer!

Fatty liver or Non-alcoholic fatty liver disease (NAFLD) refers to fatty accumulation within the liver. When fat accumulation progresses, an inflammatory process is initiated within the liver parenchyma. This is marked by an increase in liver enzymes and called nonalcoholic steatohepatitis. Nonalcoholic steatohepatitis (NASH) may progress to a stage of cirrhosis and Fibrosis in a …

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Congenital Adrenal Hyperplasia (CAH) – Diagnosis!

Congenital Adrenal Hyperplasia is an uncommon cause of hypertension in young patients. This 32-year-old patient, unmarried, and a watchman by profession was referred to the PIMS surgery department for resection of an abdominal mass. The abdominal mass was investigated during his previous admissions and a laparoscopic biopsy was done which was consistent with the diagnosis …

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Uncontrolled hypertension, High Sodium, and Low potassium

A 40 years old male presented with uncontrolled hypertension of two years duration. Despite receiving beta blockers, calcium channel blockers, and an ACE inhibitor, his blood pressure remains elevated. He also complains of polyuria, polydipsia, and generalized muscle weakness. On examination, his  BP is 180/110 mmHg. Funduscopy reveals grade III hypertensive retinopathy. Rest of the …

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SGLT2 inhibitors

Severe genital infection with the use of SGLT2 inhibitors!

The incidence of a serious genital infection, the Fournier’s gangrene, has been noted to rise with the use of SGLT2 inhibitors. This has prompted the FDA to add an alert with its use. SGLT2 inhibitors include dapagliflozin, canagliflozin, empagliflozin, and ertugliflozin. These drugs have recently been marketed for the treatment of type 2 diabetes patients. …

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amenorrhea and weight gain

Amenorrhea, rapid weight gain, diabetes and hypertension

A 30 years old female was evaluated 6 months back for rapid weight gain and amenorrhea and found to have diabetes, hypertension, and obstructive sleep apnea. She presented with acute onset of a severe headache and syncope. O/E She is afebrile, BP: 130/80 (80/60 mmHg on standing), signs of meningeal irritation are positive. She has …

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sudden vision loss

Sudden vision loss, arthralgias, and Syncope!

A 40 years old female was brought to the emergency with a history of sudden vision loss. Her previous history is significant for poly-arthralgias, Raynaud’s phenomena and syncopal episodes. On Examination she has stable vital signs with no postural drop in blood pressure. Fundus examination reveals retinal whitening. The cardiovascular examination is significant for a …

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